Vitamin D and Increased 1,25-dihydroxyvitamin D Level

• Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis.

  • 2024-05-07
  • Meta-Analysis · n = 770
  • International journal of molecular sciences 25(10)
  • • Kamila Bokayeva
    • Małgorzata Jamka
    • Dariusz Walkowiak
    • Monika Duś-Żuchowska
    • Karl-Heinz Herzig
    • Jarosław Walkowiak

  • PubMed: 38791104
  • DOI: 10.3390/ijms25105065

  12 Insights on

  • Increased 1,25-dihydroxyvitamin D Level

  • High evidence
  • Rigorous Journal
  • Clinical

  PKU patients demonstrated significantly higher ... 1,25-dihydroxyvitamin D concentrations (random-effects model, SMD: 2.059, 95% CI: 0.250, 3.868, p = 0.026)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

• Short-Term Effects of Escalating Doses of Cholecalciferol on FGF23 and 24,25(OH)2 Vitamin D Levels: A Preliminary Investigation.

  • 2024-10-23
  • RCT
  • Nutrients 16(21)
  • • Jessica Pepe
    • Luciano Colangelo
    • Roberta Pilotto
    • Viviana De Martino
    • Carla Ferrara
    • Alfredo Scillitani
    • Mirella Cilli
    • Salvatore Minisola
    • Ravinder Singh
    • Cristiana Cipriani

  • PubMed: 39519433
  • DOI: 10.3390/nu16213600

  10 Insights on

  • Increased 1,25-dihydroxyvitamin D Level

  • High evidence
  • Rigorous Journal
  • Clinical

  In the group administered 600,000 I.U., there was a significant increase in the delta changes in 25(OH)D and 1,25(OH)2D compared to the placebo and in the delta 24,25(OH)D2 compared to the placebo and 25,000 I.U. groups (all p < 0.05).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  600,000 I.U. single oral dose