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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Increased 25(OH)D3 Level

Doses used in studies

IU single-dose: 500,000 (median 500,000, IQR 500,000–500,000) — 1 study

Safety in these studies

Overall tolerabilityReported
High-dose cholecalciferol supplementation was well tolerated
from: Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metaboli

1 of 1 paper

Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metabolites in Professional Football Players: A Pilot Study.
- 2026-01-05
- RCT
- Nutrients 18(1)
- - Anna Książek
  - Aleksandra Zagrodna
  - Konrad Kowalski
- PubMed: 41515291
- DOI: 10.3390/nu18010175
3 Insights on
- Increased 25(OH)D3 Level
- High evidence
- Rigorous Journal
- Athletes
Following supplementation, these effects were further amplified, with 25-(OH)D3 rising by 98%
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
500,000 IU single dose