Vitamin D and Increased Complement C3 Level

Doses used in studies

D3 · IU/week: 17,000 (median 17,000, IQR 17,000–17,000) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 1 study

1 of 1 paper

High- vs. routine-dose vitamin D3 in severe lupus on pulse methylprednisolone: a randomized, double-blind, placebo-controlled clinical trial.

2025-08-16
RCT · n = 20
Clinical rheumatology 44(10)
- Lisbeth A Aguila
- Rosa M R Pereira
- Luciana P Seguro
- Michelle R Ugolini-Lopes
- Lissiane K N Guedes
- Lucas P Sales
- Alan L Fernandes
- Felipe M de Santana
- Valéria F Caparbo
- Liliam Takayama
- Eduardo F Borba
- Diogo S Domiciano

PubMed: 40818016
DOI: 10.1007/s10067-025-07633-3

4 Insights on

Increased Complement C3 Level

High evidence
Clinical

ROC analysis identified Δ25OHD cutoffs of 12.9 ng/ml (AUC = 0.741) for C3 ... normalization, indicating that exceeding these may improve complement normalization.

Effect: Neutral
Effect size: Small
Significant: No
Dose: High-dose group: 100,000 IU vitamin D3 plus 7,000 IU weekly; Routine-dose group: placebo plus 7,000 IU weekly