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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Increased Complement C4 Level

Doses used in studies

D3 · IU/week: 17,000 (median 17,000, IQR 17,000–17,000) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 1 study

1 of 1 paper

High- vs. routine-dose vitamin D3 in severe lupus on pulse methylprednisolone: a randomized, double-blind, placebo-controlled clinical trial.
- 2025-08-16
- RCT · n = 20
- Clinical rheumatology 44(10)
- - Lisbeth A Aguila
  - Rosa M R Pereira
  - Luciana P Seguro
  - Michelle R Ugolini-Lopes
  - Lissiane K N Guedes
  - Lucas P Sales
  - Alan L Fernandes
  - Felipe M de Santana
  - Valéria F Caparbo
  - Liliam Takayama
  - Eduardo F Borba
  - Diogo S Domiciano
- PubMed: 40818016
- DOI: 10.1007/s10067-025-07633-3
4 Insights on
- Increased Complement C4 Level
- High evidence
- Clinical
there was a trend toward a greater ΔC4 increase in the HD group (7.38 vs. 3.27, p = 0.093)
Effect
Neutral
Effect size
Small
Significant
No
Dose
High-dose group: 100,000 IU vitamin D3 plus 7,000 IU weekly; Routine-dose group: placebo plus 7,000 IU weekly