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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Increased High-Density Lipoprotein Cholesterol

Doses used in studies

IU/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 6 weeks · IQR 6 weeks–6 weeks · Range 6 weeks–6 weeks — Reported in 1 of 2 studies

2 of 2 papers

Vitamin D and Evening Primrose Oil Administration Improve Glycemia and Lipid Profiles in Women with Gestational Diabetes.
- 2016-01-19
- RCT · n = 60
- Lipids 51(3)
- - Mehri Jamilian
  - Maryam Karamali
  - Mohsen Taghizadeh
  - Nasrin Sharifi
  - Zahra Jafari
  - Mohammad Reza Memarzadeh
  - Mahnaz Mahlouji
  - Zatolla Asemi
- PubMed: 26781763
- DOI: 10.1007/s11745-016-4123-3
9 Insights on
- Increased High-Density Lipoprotein Cholesterol
- High evidence
- Clinical
We did not observe any significant effect of vitamin D and EPO supplementation on serum HDL concentrations.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1000 IU/day
Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-04
- Meta-Analysis
- The Journal of nutrition 156(4)
- - Bowen Yu
  - Junyan Liu
  - Fangfang Bu
  - Hongli Yan
  - Chen Chen
  - Yanfei Li
  - Yifei Sun
  - Yaqin Wang
  - Junhua Yuan
- PubMed: 41478593
- DOI: 10.1016/j.tjnut.2025.101314
9 Insights on
- Increased High-Density Lipoprotein Cholesterol
- High evidence
- Clinical
Pooled analysis demonstrated that vitamin D supplementation significantly reduced: ... whereas increasing HDL cholesterol (0.30; 95% CI: 0.01, 0.59).
Effect
Beneficial
Effect size
Small
Significant
Yes