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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Increased Serum Albumin Levels

Doses used in studies

IU/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
Pairwise meta-analyses showed that combination therapies significantly improved serum 25-hydroxyvitamin D levels, reduced bone-specific alkaline phosphatase, and increased serum calcium and phosphate concentrations, without an increased risk of adverse events.
from: Comprehensive evaluation of the efficacy and safety of different vitamin D combination reg

2 of 2 papers

Comprehensive evaluation of the efficacy and safety of different vitamin D combination regimens based on indirect comparisons for children with rickets: a network meta-analysis.
- 2026-04-08
- Systematic Review · n = 867
- Frontiers in nutrition 13
- - Yunfeng Cao
  - Yan Zheng
  - Yaling Chen
  - Qihua Chen
  - Xinbin Xia
  - Ziyi Yuan
  - Honghui Li
- PubMed: 42027572
- DOI: 10.3389/fnut.2026.1785775
4 Insights on
- Increased Serum Albumin Levels
- High evidence
- Clinical
Pairwise meta-analyses showed that combination therapies significantly improved serum 25-hydroxyvitamin D levels
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis.
- 2024-07-09
- RCT · n = 47
- BMC infectious diseases 24(1)
- - Rasha Eletreby
  - Aisha Elsharkawy
  - Rahma Mohamed
  - Mai Hamed
  - Eman Kamal Ibrahim
  - Rabab Fouad
- PubMed: 38982373
- DOI: 10.1186/s12879-024-09367-0
7 Insights on
- Increased Serum Albumin Levels
- High evidence
- Clinical
Patients in VD3 supplementation group had significantly higher weight gain and serum albumin level at 2 months and end of treatment
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
50,000 IU once a week for 6 weeks (total 300,000 IU), followed by maintenance doses of 1,000 IU/day