Vitamin D and Increased Sex Hormone-Binding Globulin Level

• The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta-analysis.

  • 2025-11-24
  • Meta-Analysis
  • Diabetes, obesity & metabolism 28(2)
  • • Zehra Margot Çelik
    • Döndü Kurnaz
    • Aysel Özcan
    • Ecem Keskin
    • Elif Sayın Ünlügedik
    • Şule Aktaç

  • PubMed: 41287200
  • DOI: 10.1111/dom.70307

  3 Insights on

  • Increased Sex Hormone-Binding Globulin Level

  • High evidence
  • Clinical

  Vitamin D supplementation showed the strongest metabolic and hormonal improvements.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes