Vitamin D and Increased Sputum Smear Conversion

• Efficacy and safety of vitamin D supplementation in treating pulmonary tuberculosis: a systematic review and meta-analysis.

  • 2026-04-22
  • Meta-Analysis
  • BMC infectious diseases 26(1)
  • • Chunyan Fan
    • Xiaoli Ye
    • Chengpeng Wang
    • Yuqing Wu
    • Bin Tong
    • Lin Han

  • PubMed: 42021229
  • DOI: 10.1186/s12879-026-13321-7

  7 Insights on

  • Increased Sputum Smear Conversion

  • High evidence
  • Clinical

  Adjunctive VD supplementation significantly increased the sputum smear conversion (SSC) rate (RR: 1.12; 95% confidence interval (CI): 1.05–1.19; P=0.0001; high GRADE certainty; I²=46%, P=0.06)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes