Vitamin D and Increased Vitamin D3 Ratio

• Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.

  • 2019-06-14
  • RCT · n = 52
  • The Journal of clinical endocrinology and metabolism 104(12)
  • • Adrian R Martineau
    • Kenneth E Thummel
    • Zhican Wang
    • David A Jolliffe
    • Barbara J Boucher
    • Simon J Griffin
    • Nita G Forouhi
    • Graham A Hitman

  • PubMed: 31199458
  • DOI: 10.1210/jc.2019-00207

  12 Insights on

  • Increased Vitamin D3 Ratio

  • High evidence
  • Adults

  Vitamin D2 suppressed... mean ratios of ... 1α,25(OH)2D3 to 25(OH)D3

  Effect

  Harmful

  Effect size

  Small

  Significant

  Yes

  Dose

  2.5 mg (100,000 IU) oral bolus doses monthly for 4 months