Vitamin D and Reduced Anti-Thyroid Peroxidase Antibody Level

• Vitamin D deficiency in Hashimoto's thyroiditis: mechanisms, immune modulation, and therapeutic implications.

  • 2025-08-01
  • Review
  • Frontiers in endocrinology 16
  • • Wencong Sun
    • Chao Ding
    • Yichen Wang
    • Guoqing Li
    • Zijie Su
    • Xinhui Wang

  • PubMed: 40822954
  • DOI: 10.3389/fendo.2025.1576850

  2 Insights on

  • Reduced Anti-Thyroid Peroxidase Antibody Level

  • Low evidence
  • Clinical

  Supplementation (2000-4000 IU/day) reduces antibodies by 15-30% only in euthyroid TPOAb+ patients with baseline deficiency (<20 ng/mL)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  2000-4000 IU/day