The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausal women with osteoporosis: a systematic review and meta-analysis of randomized controlled trials.
- 2025-10-08
- Meta-Analysis · n = 869
- BMC musculoskeletal disorders 26(1)
- Bo Cong
- Haiguang Zhang
- PubMed: 41063100
- DOI: 10.1186/s12891-025-09089-7
- High evidence
- Clinical
Fracture outcomes from three large trials (> 42 000 participants) yielded a neutral effect on any clinical fracture (pooled RR = 0.95; 95% CI 0.85–1.07; Z = 1.08, P = 0.28; I² = 0%)
- Effect
- Neutral
- Effect size
- Small
- Significant
- No