Vitamin D and Reduced Cognitive Decline

• Neurobiological mechanisms linking vitamin d signaling to cognitive decline and neurodegeneration: Untangling epidemiology, pathophysiology, and evidence.

  • 2026-03-20
  • Review
  • World journal of experimental medicine 16(1)
  • • Neha Choudhary
    • Maheen Zahid
    • Muhammad Ahmad
    • Muneeba Shaukat
    • Muhammad Tariq
    • Soura Rajeshwara
    • Shermeen Usman
    • Taimoor Wajid
    • Ayoola Awosika

  • PubMed: 41883434
  • DOI: 10.5493/wjem.v16.i1.118761

  3 Insights on

  • Reduced Cognitive Decline

  • Low evidence

  large randomized trials in generally healthy older adults, including VITAL and D-Health, report null effects

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• Cholecalciferol (vitamin D3): efficacy, safety, and implications in public health.

  • 2025-06-09
  • Review
  • Frontiers in nutrition 12
  • • Esteban Ortiz-Prado
    • Jorge Vasconez-Gonzalez
    • Juan S Izquierdo-Condoy
    • Isaac A Suárez-Sangucho
    • José Guillermo Prieto-Marín
    • Karen Bereniss Villarreal-Burbano
    • Mateo Alejandro Barriga-Collantes
    • John Alexander Altamirano-Castillo
    • Domenic Anahi Borja-Mendoza
    • Jean Carlo Pazmiño-Almeida
    • María Paz Cadena-Padilla

  • PubMed: 40551736
  • DOI: 10.3389/fnut.2025.1579957

  7 Insights on

  • Reduced Cognitive Decline

  • Low evidence

  large-scale randomized controlled trials (RCTs) have yielded mixed or inconclusive results, particularly in cancer, cardiovascular events, and cognitive decline.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No