Vitamin D and Reduced Dementia Incidence

Doses used in studies

IU/day: 3,200 (median 3,200, IQR 3,200–3,200) — 1 study

Time to effect

Median: 60.8 months · IQR 60.8 months–60.8 months · Range 60.8 months–60.8 months — Reported in 1 of 1 study

1 of 1 paper

The Effect of Vitamin D3 Supplementation on the Incidence of Diagnosed Dementia Among Healthy Older Adults-The Finnish Vitamin D Trial.

2025-04-17
RCT · n = 550
The journals of gerontology. Series A, Biological sciences and medical sciences 80(7)
- Eija Lönnroos
- Maija Ylilauri
- Christel Lamberg-Allardt
- JoAnn E Manson
- Tarja Nurmi
- Matti Uusitupa
- Ari Voutilainen
- Sari Hantunen
- Tomi-Pekka Tuomainen
- Jyrki K Virtanen

PubMed: 40243375
DOI: 10.1093/gerona/glaf077

2 Insights on

Reduced Dementia Incidence

High evidence
Large Human Trial
Clinical

During the mean follow-up of 4.2 years, 18 participants in the placebo arm, 14 participants in the 1,600 IU/d arm (compared to placebo, hazard ratio [HR] = 0.77, 95% confidence interval [CI]: 0.38-1.55), and 13 participants in the 3,200 IU/d arm (HR = 0.72, 95% CI: 0.35-1.48) were diagnosed with dementia.

Effect: Neutral
Effect size: Small
Significant: No
Dose: 3,200 IU/day