Vitamin D and Reduced Dephosphorylated-Uncarboxylated Matrix Gla Protein Level

Doses used in studies

mcg/day: 25 (median 25, IQR 25–25) — 1 study

Time to effect

Median: 24.3 months · IQR 24.3 months–24.3 months · Range 24.3 months–24.3 months — Reported in 1 of 1 study

1 of 1 paper

Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.

2022-05-03
RCT · n = 365
Circulation 145(18)
- Axel C P Diederichsen
- Jes S Lindholt
- Sören Möller
- Kristian A Øvrehus
- Søren Auscher
- Jess Lambrechtsen
- Susanne E Hosbond
- Dilek H Alan
- Grazina Urbonaviciene
- Søren W Becker
- Maise H Fredgart
- Selma Hasific
- Lars Folkestad
- Oke Gerke
- Lars Melholt Rasmussen
- Jacob E Møller
- Hans Mickley
- Jordi S Dahl

PubMed: 35465686
DOI: 10.1161/circulationaha.121.057008

1 Insight on

Reduced Dephosphorylated-Uncarboxylated Matrix Gla Protein Level

High evidence
Large Human Trial
Rigorous Journal
Clinical

Compared with patients in the placebo arm, a significant reduction in dp-ucMGP was observed with MK-7 plus vitamin D (-212 pmol/L versus 45 pmol/L; P<0.001).

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 25 µg/day