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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Diabetes Risk

Doses used in studies

IU/day: 4,000 (median 4,000, IQR 4,000–4,000) — 1 study

Time to effect

Median: 30.4 months · IQR 30.4 months–30.4 months · Range 30.4 months–30.4 months — Reported in 1 of 1 study

1 of 1 paper

Vitamin D Receptor Polymorphisms and the Effect of Vitamin D Supplementation on Diabetes Risk Among Adults With Prediabetes.
- 2026-04-23
- RCT · n = 2,098
- JAMA network open 9(4)
- - Bess Dawson-Hughes
  - Gordon S Huggins
  - Jason Nelson
  - Ellen Vickery
  - Sarah N Powers
  - Anastassios G Pittas
- PubMed: 42024385
- DOI: 10.1001/jamanetworkopen.2026.7332
1 Insight on
- Reduced Diabetes Risk
- High evidence
- Large Human Trial
- Rigorous Journal
- Clinical
1480 participants with ApaI AC and CC genotypes showed a 19% decrease in the risk of diabetes with vitamin D3 (HR, 0.81 [95% CI, 0.66-0.99])
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
4000 IU/day