Vitamin D and Reduced Disease Activity

• Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis.

  • 2026-05
  • Meta-Analysis · n = 847
  • Autoimmunity reviews 25(5)
  • • Jiale Lu
    • Qingmiao Zhu
    • Jiaxun Yu
    • Zhuchen Tan
    • Yingxin Kang
    • Qice Sun
    • Ting Zhao

  • PubMed: 41951148
  • DOI: 10.1016/j.autrev.2026.104057

  4 Insights on

  • Reduced Disease Activity

  • High evidence
  • Clinical

  Vitamin D supplementation significantly improved serum 25(OH)D status (SMD = 3.46, p < 0.001) and reduced disease activity in SLE (SMD = -0.54, p < 0.001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes