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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Estrogen Rise Rate

Doses used in studies

IU/week: 4,200–50,000 (median 27,100, IQR 4,200–50,000) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

1 of 1 paper

The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.
- 2026-01
- RCT
- Contemporary clinical trials 160
- - Michelle R Klawans
  - Olivia Kohrman
  - W Braxton Jackson
  - Chandra L Jackson
  - Christine N Metz
  - Ganesa Wegienka
  - Alison Motsinger-Reif
  - Anne Z Steiner
  - Donna D Baird
  - Dale P Sandler
  - Anne Marie Z Jukic
- PubMed: 41352534
- DOI: 10.1016/j.cct.2025.108176
3 Insights on
- Reduced Estrogen Rise Rate
- High evidence
- Adults
The primary endpoints were mid-luteal progesterone, rate of estrogen rise, and pre-ovulatory luteinizing hormone.
Effect
Neutral
Effect size
Small
Significant
No
Dose
4200 IU/week or 50,000 IU/week