Vitamin D and Reduced Faecal Calprotectin

Doses used in studies

IU single-dose: 2,000–800,000 (median 401,000, IQR 2,000–800,000) — 1 study

Time to effect

Median: 6.6 months · IQR 3.7 months–9.4 months · Range 4 weeks–12.2 months — Reported in 2 of 2 studies

2 of 2 papers

The Assessment of Multidimensional Clinical, Biological and Patient-Reported Outcomes to Evaluate the Efficacy of Add-On Lactobacillus rhamnosus GG Supplementation in Mild Ulcerative Colitis: A Randomized Pilot Trial.
- 2026-04-23
- RCT
- Nutrients 18(9)
- - Paola Maragno
  - Chiara Amoroso
  - Simone Conforti
  - Marco Michelon
  - Ivanna Honcharyuk
  - Clorinda Ciafardini
  - Daniele Noviello
  - Francesco Strati
  - Flavio Caprioli
  - Federica Facciotti
  - Maurizio Vecchi
- PubMed: 42123931
- DOI: 10.3390/nu18091329
5 Insights on
- Reduced Faecal Calprotectin
- High evidence
- Rigorous Journal
- Clinical
LGG+VitD3-supplemented patients showed reduced fecal calprotectin levels
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
not specified in abstract
Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.
- 2025-02-28
- RCT · n = 74
- Digestive diseases and sciences 70(5)
- - Jonathan E M O'Donnell
  - Steven T Leach
  - Nerissa L Bowcock
  - Siying Chen
  - Nitin Gupta
  - Kevin Jiang
  - Robert N Lopez
  - Rachel Messenger
  - Lily Nahidi
  - Amanda Shapiro
  - Andrew S Day
  - Daniel A Lemberg
- PubMed: 40021606
- DOI: 10.1007/s10620-025-08913-3
12 Insights on
- Reduced Faecal Calprotectin
- High evidence
- Rigorous Journal
- Clinical
There was no difference in biochemical, stool or clinical markers between groups at any time point, nor was there any correlation between 25OHD level and calprotectin
Effect
Neutral
Effect size
Small
Significant
No
Dose
2000 IU daily or 400,000 IU (3-12 years) or 800,000 IU (>12 years) single dose

Vitamin D and Reduced Faecal Calprotectin

The Assessment of Multidimensional Clinical, Biological and Patient-Reported Outcomes to Evaluate the Efficacy of Add-On Lactobacillus rhamnosus GG Supplementation in Mild Ulcerative Colitis: A Randomized Pilot Trial.

Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.