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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Fall Risk

Doses used in studies

IU/day: 2,000–4,000 (median 3,000, IQR 2,000–4,000) — 1 study

Safety in these studies

fallIncreased risk
growing evidence suggesting an increased fall risk associated with high-dose bolus administration
from: Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.

2 of 2 papersPopulation:

Effectiveness of Vitamin D Supplements in Reducing the Risk of Falls among Older Adults: A Meta-Analysis of Randomized Controlled Trials.
- 2023-09-30
- Meta-Analysis
- Annals of geriatric medicine and research 27(3)
- - Tiara Octary
  - Made Satya Nugraha Gautama
  - Hai Duong
- PubMed: 37654099
- DOI: 10.4235/agmr.23.0047
2 Insights on
- Reduced Fall Risk
- High evidence
- Elderly
Pooled subgroup analysis showed that neither low (<2,000 IU/day) nor high (≥2,000 and <4,000 IU/day) doses of vitamin D supplementation had any significant effect on the incidence of falls and fractures.
Effect
Neutral
Effect size
Small
Significant
No
Dose
≥2000 and <4000 IU/day
Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials.
- 2026-04-30
- Review
- Endocrinology and metabolism (Seoul, Korea) 41(2)
- - Sung Hye Kong
- PubMed: 42114835
- DOI: 10.3803/enm.2026.2938
3 Insights on
- Reduced Fall Risk
- Low evidence
recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations.
Effect
Neutral
Effect size
Small
Significant
No
Dose
high-dose bolus administration