Vitamin D and Reduced Matrix Metalloproteinase-1 Level

• Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial.

  • 2026-01-08
  • RCT · n = 126
  • British journal of cancer 134(6)
  • • Tafirenyika Gwenzi
    • Alexander N R Weber
    • Kira Trares
    • Tomislav Vlaski
    • Marija Slavic
    • Sha Sha
    • Edelmann Dominic
    • Reiner Caspari
    • Bettine Bilsing
    • Harald Fischer
    • Cristina-Maria Fernandes-Almeida
    • David Czock
    • Ben Schöttker
    • Hermann Brenner

  • PubMed: 41507560
  • DOI: 10.1038/s41416-025-03333-6

  3 Insights on

  • Reduced Matrix Metalloproteinase-1 Level

  • High evidence
  • Large Human Trial
  • Clinical

  The reductions observed in IFN-γ and MMP-1 due to VIDS were not statistically significant (... -5.4%; p = 0.23, respectively).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  personalized loading dose followed by 2000 IU/day maintenance