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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Neutrophil-to-Lymphocyte Ratio

Doses used in studies

IU single-dose: 300,000 (median 300,000, IQR 300,000–300,000) — 1 study
IU/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 2 studies

2 of 2 papers

Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.
- 2025-05-12
- RCT
- Frontiers in immunology 16
- - Samira Rastgoo
  - Katayoun Pourvali
  - Seyed Ahmad Raeissadat
  - Ghazaleh Eslamian
  - Hamid Zand
- PubMed: 40421021
- DOI: 10.3389/fimmu.2025.1570441
6 Insights on
- Reduced Neutrophil-to-Lymphocyte Ratio
- High evidence
- Clinical
No significant differences were observed between the groups in ... the neutrophil-to-lymphocyte ratio (NLR) after the intervention.
Effect
Neutral
Effect size
Small
Significant
No
Dose
600 mg daily
Investigating the Effect of High-Dose Vitamin D3 Administration on Inflammatory Biomarkers in Patients with Moderate to Severe Traumatic Brain Injury: A Randomized Clinical Trial.
- 2024-10-01
- RCT
- Iranian journal of medical sciences 49(10)
- - Farnoosh Masbough
  - Mehran Kouchek
  - Mohsen Koosha
  - Sara Salarian
  - Mirmohammad Miri
  - Masoomeh Raoufi
  - Niloufar Taherpour
  - Saied Amniati
  - Mohammad Sistanizad
- PubMed: 39449769
- DOI: 10.30476/ijms.2023.99465.3156
6 Insights on
- Reduced Neutrophil-to-Lymphocyte Ratio
- High evidence
- Clinical
reduction in NLR (P=0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
single intramuscular dose of 300,000 IU