Vitamin D and Reduced p16 Expression

• Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.

  • 2025-05-12
  • RCT
  • Frontiers in immunology 16
  • • Samira Rastgoo
    • Katayoun Pourvali
    • Seyed Ahmad Raeissadat
    • Ghazaleh Eslamian
    • Hamid Zand

  • PubMed: 40421021
  • DOI: 10.3389/fimmu.2025.1570441

  6 Insights on

  • Reduced p16 Expression

  • High evidence
  • Clinical

  co-administration of NAC with 1000 IU of Vit-D significantly downregulated p16 transcripts in PBMCs compared to Vit-D 1000 IU alone.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  600 mg daily