Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Ratio of 24R,25-Dihydroxyvitamin D3 to 25-Hydroxyvitamin D3

Doses used in studies

mg single-dose: 2.5 (median 2.5, IQR 2.5–2.5) — 1 study

Time to effect

Median: 4 months · IQR 4 months–4 months · Range 4 months–4 months — Reported in 1 of 1 study

1 of 1 paper

Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.
- 2019-06-14
- RCT · n = 52
- The Journal of clinical endocrinology and metabolism 104(12)
- - Adrian R Martineau
  - Kenneth E Thummel
  - Zhican Wang
  - David A Jolliffe
  - Barbara J Boucher
  - Simon J Griffin
  - Nita G Forouhi
  - Graham A Hitman
- PubMed: 31199458
- DOI: 10.1210/jc.2019-00207
12 Insights on
- Reduced Ratio of 24R,25-Dihydroxyvitamin D3 to 25-Hydroxyvitamin D3
- High evidence
- Adults
Mean postsupplementation ratios of 24R,25(OH)2D3 to 25(OH)D3 ... did not differ between groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2.5 mg (100,000 IU) oral bolus doses monthly for 4 months