Vitamin D and Reduced Systolic Blood Pressure

• The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.

  • 2026-01-13
  • Review
  • Frontiers in pediatrics 13
  • • Xiao Zhou
    • Yuhe Chen
    • Jianxin Xu
    • Xiaobing Li
    • Yanmei Wu
    • Lidan Xu

  • PubMed: 41608325
  • DOI: 10.3389/fped.2025.1700949

  2 Insights on

  • Reduced Systolic Blood Pressure

  • Low evidence
  • Clinical

  Meta-analysis of 12 randomised trials (n = 1,538) revealed that vitamin D supplementation improves insulin sensitivity and lowers systolic blood pressure only when baseline 25-hydroxyvitamin D (25(OH)D) is <20 ng/mL and systemic inflammation is modest

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  4,000 IU/day