Vitamin D and Reduced Systolic Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-to-moderate effects of vitamin D on reducing systolic blood pressure, while 1 found no significant effect. The largest meta-analysis (evidence score 4) showed a small but significant reduction (MD: -2.83 mmHg). Evidence is limited and mixed by study design and population, with no clear convergence on dose or form.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One meta-analysis found significant benefit only in specific subgroups (baseline 25(OH)D <20 ng/mL and moderate inflammation), and the neutral study used vitamin D2, suggesting form may matter.

Generated Jul 12, 2026

Doses used in studies

IU/day: 4,000 (median 4,000, IQR 4,000–4,000) — 1 study

3 of 3 papersPopulation:

Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.
- 2025-03-05
- Meta-Analysis
- BMC complementary medicine and therapies 25(1)
- - Samar A Amer
  - Dina Essam Abo-Elnour
  - Abdallah Abbas
  - Abdelrahman Salah Abdelrahman
  - Hossam-Eldin Mohamed Hamdy
  - Samar Kenawy
  - Menna M Sarhan
  - Omar Hany Mohamed
  - Mohamed Yousif Elnaghy
  - Mohammed Baker
  - Rawan Medhat El-Gayar
  - Omnia Samy El-Sayed
  - Moamen Mostafa Asla
- PubMed: 40045266
- DOI: 10.1186/s12906-025-04809-x
3 Insights on
- Reduced Systolic Blood Pressure
- High evidence
The estimated effect of Vit-D showed a significant reduction in SBP (MD: -2.83, 95% CI [-5.47, -0.199], P = 0.04)
Effect
Beneficial
Effect size
Small
Significant
Yes
The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials.
- 2024-10
- Meta-Analysis
- Prostaglandins & other lipid mediators 174
- - Zhihong Zhou
  - Jiyuan Liu
  - Hui Zhang
  - Kousalya Prabahar
  - Benjamin Hernández-Wolters
  - Yuanhong Yuan
- PubMed: 39154789
- DOI: 10.1016/j.prostaglandins.2024.106883
12 Insights on
- Reduced Systolic Blood Pressure
- High evidence
No statistically significant association was observed between vitamin D2 administration and ... SBP
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified
The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.
- 2026-01-13
- Review
- Frontiers in pediatrics 13
- - Xiao Zhou
  - Yuhe Chen
  - Jianxin Xu
  - Xiaobing Li
  - Yanmei Wu
  - Lidan Xu
- PubMed: 41608325
- DOI: 10.3389/fped.2025.1700949
2 Insights on
- Reduced Systolic Blood Pressure
- Low evidence
- Clinical
Meta-analysis of 12 randomised trials (n = 1,538) revealed that vitamin D supplementation improves insulin sensitivity and lowers systolic blood pressure only when baseline 25-hydroxyvitamin D (25(OH)D) is <20 ng/mL and systemic inflammation is modest
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
4,000 IU/day

Vitamin D and Reduced Systolic Blood Pressure

Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.

The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials.

The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.