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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Systolic Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-to-moderate effects of vitamin D supplementation on reducing systolic blood pressure, while 1 found no significant association. The most notable benefit was observed in a 2025 meta-analysis showing a small but significant reduction (MD: -2.83 mmHg, 95% CI [-5.47, -0.199], P=0.04). One review reported moderate beneficial effects specifically in obese youths with baseline vitamin D deficiency (<20 ng/mL). Dose and form data were inconsistently reported, though one study used 4,000 IU/day.

  • Effective dose range: 4,000 IU/day
  • Studied populations: obese youths with vitamin D deficiency

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One study showed benefit only in individuals with baseline 25(OH)D <20 ng/mL and modest systemic inflammation, suggesting the effect may not generalize to those with sufficient vitamin D levels or without inflammation.

Generated Jun 11, 2026
Doses used in studies
  • IU/day: 4,000 (median 4,000, IQR 4,000–4,000) — 1 study
3 of 3 papers
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