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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Uric Acid Levels

Doses used in studies

IU/day: 400–800 (median 600, IQR 400–800) — 1 study

Time to effect

Median: 6.1 months · IQR 6.1 months–6.1 months · Range 6.1 months–6.1 months — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
Vitamin D supplementation shows variable effects, it should not be considered a stand-alone therapy for PCOS.
from: The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systema

2 of 2 papers

The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review.
- 2026-03-19
- Systematic Review · n = 1,063
- Nutrients 18(6)
- - Batoul Jaafar
  - Nour Chami
  - Mohamad Tlais
  - Maria Matar
  - Nazih Obeid
  - Nadia Taha
  - Karim El Haddad
  - Jessica Abou Chaaya
  - Sami Azar
- PubMed: 41901143
- DOI: 10.3390/nu18060968
7 Insights on
- Reduced Uric Acid Levels
- High evidence
- Rigorous Journal
- Clinical
Observational studies demonstrated inverse associations between serum 25(OH)D levels and insulin resistance, body mass index (BMI), and leptin, but not with total testosterone.
Effect
Neutral
Effect size
Small
Significant
Yes
Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency.
- 2025-05-30
- RCT · n = 44
- European journal of nutrition 64(5)
- - Xiaoyun Shan
  - Wenxuan Wu
  - Jingxin Yang
  - Yang Cao
  - Yuting Li
  - Yichun Hu
  - Rui Wang
  - Lichen Yang
- PubMed: 40445221
- DOI: 10.1007/s00394-025-03723-9
4 Insights on
- Reduced Uric Acid Levels
- High evidence
- Rigorous Journal
- Clinical
There was no statistically significant difference in the effect of the intervention between the two dose groups
Effect
Neutral
Effect size
Small
Significant
No
Dose
400 IU/day vs 800 IU/day