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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Uric Acid Levels

Research synthesisVery low evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies, the evidence shows neutral effects of vitamin D on uric acid levels, with no studies reporting beneficial or harmful outcomes. The predominant effect size is small, and the median study duration was 147 days. The majority of studies involved clinical populations, including women with PCOS and hypertensive obese OSA patients.

  • Studied populations: women with PCOS, hypertensive obese OSA patients

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jun 11, 2026
Doses used in studies
  • IU/day: 400–800 (median 600, IQR 400–800) — 1 study
Time to effect
Median: 4.9 months · IQR 4.3 months–5.5 months · Range 3.7 months–6.1 months — Reported in 2 of 3 studies
Safety in these studies
3 of 3 papers
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