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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Vitamin D Deficiency

Doses used in studies

IU single-dose: 2,000–800,000 (median 401,000, IQR 2,000–800,000) — 1 study

Time to effect

Median: 12.2 months · IQR 12.2 months–12.2 months · Range 12.2 months–12.2 months — Reported in 1 of 1 study

1 of 1 paper

Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.
- 2025-02-28
- RCT · n = 74
- Digestive diseases and sciences 70(5)
- - Jonathan E M O'Donnell
  - Steven T Leach
  - Nerissa L Bowcock
  - Siying Chen
  - Nitin Gupta
  - Kevin Jiang
  - Robert N Lopez
  - Rachel Messenger
  - Lily Nahidi
  - Amanda Shapiro
  - Andrew S Day
  - Daniel A Lemberg
- PubMed: 40021606
- DOI: 10.1007/s10620-025-08913-3
12 Insights on
- Reduced Vitamin D Deficiency
- High evidence
- Rigorous Journal
- Clinical
Both 2000 IU daily and stoss protocol significantly increased 25OHD from baseline values at 3, 6, 9 and 12 months.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
400,000 IU (3-12 years) or 800,000 IU (>12 years) single dose