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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced White Blood Cell Count

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Efficacy and safety of vitamin D supplementation in treating pulmonary tuberculosis: a systematic review and meta-analysis.
- 2026-04-22
- Meta-Analysis
- BMC infectious diseases 26(1)
- - Chunyan Fan
  - Xiaoli Ye
  - Chengpeng Wang
  - Yuqing Wu
  - Bin Tong
  - Lin Han
- PubMed: 42021229
- DOI: 10.1186/s12879-026-13321-7
7 Insights on
- Reduced White Blood Cell Count
- High evidence
- Clinical
whereas no significant effects were detected for white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), or C-reactive protein (CRP).
Effect
Neutral
Effect size
Small
Significant
No
Effects of vitamin D3 supplementation on cardiac, muscle, and immune responses after a marathon race: a single-blind, placebo-controlled trial.
- 2026-04-12
- RCT
- Journal of the International Society of Sports Nutrition 23(1)
- - Pei-Wei Weng
  - Josephine Diony Nanda
  - Yu-Hsiu Chien
  - Chiou-Feng Lin
  - Shih-Chung Cheng
  - Ming-Ta Yang
- PubMed: 41966073
- DOI: 10.1080/15502783.2026.2657316
8 Insights on
- Reduced White Blood Cell Count
- High evidence
- Athletes
Both groups showed post-race increases in white blood cell counts, particularly neutrophils, whereas lymphocyte counts significantly decreased at 0.5 h and 2 h post-race.
Effect
Neutral
Effect size
Small
Significant
No