Vitamin D and Shifted Fecal Metabolite Network

Doses used in studies

IU/day: 4,000 (median 4,000, IQR 4,000–4,000) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

1 of 1 paper

Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults.

2024-10-03
RCT
Microbiology spectrum 12(10)
- Madhur Wyatt
- Ankan Choudhury
- Gabriella Von Dohlen
- Jeffery L Heileson
- Jeffrey S Forsse
- Sumudu Rajakaruna
- Manja Zec
- Malak M Tfaily
- Leigh Greathouse

PubMed: 39189761
DOI: 10.1128/spectrum.00083-24

4 Insights on

Shifted Fecal Metabolite Network

High evidence
Adults

vitamin D₃ supplementation resulted in notable metabolic shifts, in addition to resulting in a drastic rewiring of key gut microbial-metabolic associations

Effect: Neutral
Effect size: Small
Significant: No
Dose: 4,000 IU/day for 12 weeks