Vitamin D2 and Improved Appendicular Skeletal Muscle Mass Index

Doses used in studies

units/week: 300,000 (median 300,000, IQR 300,000–300,000) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
No other clinically significant differences were observed between the groups in the remaining secondary clinical and safety endpoints.
from: Effect of vitamin D supplementation on skeletal muscle function and quality of life in pat

1 of 1 paper

Effect of vitamin D supplementation on skeletal muscle function and quality of life in patients with chronic intestinal failure: a randomized controlled trial : Clean version.

2025-12-25
RCT · n = 42
Journal of translational medicine 24(1)
- Xuejin Gao
- Sirui Liu
- Yupeng Zhang
- Yufei Xia
- Sitong Liu
- Xin Qi
- Yaqin Xiao
- Minyi Zhu
- Guangming Sun
- Tingting Gao
- Li Zhang
- Xinying Wang

PubMed: 41449463
DOI: 10.1186/s12967-025-07607-8

5 Insights on

Improved Appendicular Skeletal Muscle Mass Index

High evidence
Clinical

the vitamin D group showed clinically meaningful improvements in the appendicular skeletal muscle mass index, handgrip strength, 6-meter walking speed, and the SF-36 physical component summary score (all p<0.05 after Bonferroni correction).

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 600,000 units intramuscularly every two weeks for 10 weeks