Vitamin D2 and Reduced Michigan Neuropathy Screening Instrument Score

• Efficacy and safety of high-dose intramuscular vitamin D2 injection in type 2 diabetes mellitus with distal symmetric polyneuropathy combined with vitamin D insufficiency: study protocol for a multicenter, randomized, double-blinded, and placebo-controlled trial.

  • 2023-07-07
  • RCT
  • Frontiers in endocrinology 14
  • • Tao Chen
    • Xiaoyan Xing
    • Lihua Huang
    • Mei Tu
    • Xiaoli Lai
    • Shidi Wen
    • Jin Cai
    • Shenglong Lin
    • Youping Zheng
    • Yuehui Lin
    • Lijuan Xu
    • Yuwen Qiu
    • Lumin Qiu
    • Yuebo Xu
    • Peiwen Wu

  • PubMed: 37484958
  • DOI: 10.3389/fendo.2023.1202917

  1 Insight on

  • Reduced Michigan Neuropathy Screening Instrument Score

  • High evidence
  • Clinical

  This study aims to evaluate the efficacy and safety of intramuscular injection of high-dose vitamin D (HDVD) in T2DM with DSPN combined with vitamin D insufficiency.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  high-dose intramuscular injection monthly for 3 months