Vitamin D3 and Improved Ang-(1-7)/Ang II Ratio

• Vitamin D3 supplementation in COVID-19 patients with cardiovascular disease and gut dysbiosis.

  • 2024-07
  • RCT · n = 50
  • Hipertension y riesgo vascular 41(3)
  • • R L Sanz
    • F García
    • A Gutierrez
    • S García Menendez
    • F Inserra
    • L Ferder
    • W Manucha

  • PubMed: 38871574
  • DOI: 10.1016/j.hipert.2024.04.002

  8 Insights on

  • Improved Ang-(1-7)/Ang II Ratio

  • High evidence
  • Clinical

  The Ang-(1-7)/Ang II ratio, as an indirect measure of ACE2 enzymatic activity, increased in the vitamin D3 group (24±5pg/mL vs. 4.66±2pg/mL, p<0.01).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  10,000 IU/day