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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D3 and Increased Vitamin D Level

Doses used in studies

IU/day: 6,000 (median 6,000, IQR 6,000–6,000) — 1 study

Time to effect

Median: 3.5 months · IQR 9.4 weeks–4.7 months · Range 4 weeks–6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
All participants completed the study without adverse events and with >90% adherence to the allocated treatment.
from: Immunonutritional effects elicited by a novel multicomponent food supplement in children w

2 of 2 papersPopulation:

Differential and Dose-Dependent Redistribution of Vitamin D Metabolites After Acute High-Intensity Exercise in Mixed Martial Arts Athletes and Untrained Men: Pilot Study.
- 2026-03-26
- RCT
- Nutrients 18(7)
- - Katarzyna Patrycja Dzik
  - Katarzyna Jagłowska
  - Miłosz Palicki
  - Sylwester Kujach
  - Piotr Sawicki
  - Konrad Kowalski
  - Jan Jacek Kaczor
- PubMed: 41978112
- DOI: 10.3390/nu18071061
4 Insights on
- Increased Vitamin D Level
- High evidence
- Rigorous Journal
- Athletes
Supplementation with 3500 IU/day significantly increased serum 25(OH)D3 in untrained men (p = 0.003) but not in MMA athletes.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
6000 IU/day
Immunonutritional effects elicited by a novel multicomponent food supplement in children with cow's milk allergy: results from a randomized, placebo-controlled trial.
- 2026-03-16
- Clinical Trial
- Frontiers in allergy 7
- - Laura Carucci
  - Erika Caldaria
  - Franca Oglio
  - Raffaele Federico Iorio
  - Vittoria Mauriello
  - Antonio Masino
  - Serena Coppola
- PubMed: 41918962
- DOI: 10.3389/falgy.2026.1760231
11 Insights on
- Increased Vitamin D Level
- High evidence
- Clinical
Serum 25-hydroxyvitamin D (25(OH)D) concentrations significantly improved only in the active study group
Effect
Beneficial
Effect size
Moderate
Significant
Yes