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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D3 and Reduced Risk of Insufficient 25-Hydroxyvitamin D Level

Doses used in studies

IU/week: 24,000 (median 24,000, IQR 24,000–24,000) — 1 study

Time to effect

Median: 12.2 months · IQR 12.2 months–12.2 months · Range 12.2 months–12.2 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
Supplementation was well tolerated
from: Efficacy of Vitamin D3 Supplementation in Elevating Circulating 25(OH)D Concentration in I
excess 25(OH)D levelsReported
25(OH)D levels remained well below the excess threshold
from: Efficacy of Vitamin D3 Supplementation in Elevating Circulating 25(OH)D Concentration in I

1 of 1 paper

Efficacy of Vitamin D3 Supplementation in Elevating Circulating 25(OH)D Concentration in Individuals With Chronic Spinal Cord Injury (VitD-SCI): Evidence From a Randomized, Double-Blind, Placebo-Controlled Trial.
- 2025-01
- RCT · n = 42
- Topics in spinal cord injury rehabilitation 31(4)
- - Anneke Hertig-Godeschalk
  - Martin W G Brinkhof
  - Claudio Perret
  - Anke Scheel-Sailer
  - Joelle L Flueck
- PubMed: 41268138
- DOI: 10.46292/sci24-00077
2 Insights on
- Reduced Risk of Insufficient 25-Hydroxyvitamin D Level
- High evidence
- Clinical
Vitamin D3 supplementation effectively increased 25(OH)D concentration to sufficient levels in participants with specific characteristics.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
24,000 IU once every 4 weeks (medium-dose) or 24,000 IU once every 2 weeks (high-dose)