Essential micronutrients and biguanides (metformin) synergistic and antagonistic interactions on neurocognitive outcomes in type two diabetes mellitus: a systematic review of preclinical and clinical evidence.
- 2026-02-17
- Systematic Review
- Frontiers in endocrinology 17
- Herbert Izo Ninsiima
- Herbert E Ainamani
- Geoffrey Ayebazibwe
- Daniel Matovu
- Ejike Daniel Eze
- PubMed: 41782745
- DOI: 10.3389/fendo.2026.1764157
- High evidence
Synergistic effects were observed in 77.5% of studies, with significant improvements in ... HbA1c
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes