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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin E and Improved Sperm Motility

Research synthesisVery low evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies, all reported neutral effects on sperm motility, with small effect sizes in each case. The median study duration was 87 days, and the most-studied population was men with clinical infertility (e.g., varicocelectomy patients, idiopathic infertility, oligozoospermia). Evidence is extremely limited and shows no benefit of vitamin E supplementation for improving sperm motility.

  • Studied populations: men with clinical infertility (varicocelectomy patients, idiopathic infertility, oligozoospermia/asthenospermia/teratospermia)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The two smaller RCTs compared vitamin E combined with another active intervention (M. sativa or carob) rather than vitamin E alone, complicating interpretation of vitamin E's specific effect.

Generated Jul 12, 2026
Doses used in studies
  • U single-dose: 100 (median 100, IQR 100–100) — 1 study
  • mg/day: 200 (median 200, IQR 200–200) — 1 study
Time to effect
Median: 2.9 months · IQR 2.9 months–3 months · Range 2.8 months–3 months — Reported in 2 of 3 studies
3 of 3 papers
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