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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin E and Reduced Aspartate Aminotransferase Levels

Doses used in studies

IU/day: 298–1,000 (median 649, IQR 298–1,000) — 1 study
mg/day: 300–800 (median 550, IQR 300–800) — 1 study

Time to effect

Median: 8.6 weeks · IQR 8.6 weeks–8.6 weeks · Range 8.6 weeks–8.6 weeks — Reported in 1 of 2 studies

2 of 2 papers

Vitamin E for people with non-alcoholic fatty liver disease.
- 2024-10-16
- Meta-Analysis · n = 708
- The Cochrane database of systematic reviews 2024(10)
- - Hongzhu Wen
  - Hongyong Deng
  - Lili Yang
  - Lujin Li
  - Jiang Lin
  - Peiyong Zheng
  - Milica Bjelakovic
  - Guang Ji
- PubMed: 39412049
- DOI: 10.1002/14651858.cd015033.pub2
2 Insights on
- Reduced Aspartate Aminotransferase Levels
- High evidence
- Clinical
Vitamin E likely slightly reduces ... aspartate aminotransferase (AST) (MD -4.90, 95% CI -7.24 to -2.57; 11 trials, 695 participants; moderate certainty evidence)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
298 IU to 1000 IU/day
Efficacy and Safety of Vitamin E in Adults With Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2025-07-29
- Review
- Cureus 17(7)
- - Helai Hussaini
  - Manpreet Kaur Dhanjal
  - Rahman Hameed Mohammed Abdul
  - Olaniyi Fadeyi
  - Najeeha A Bhatti
  - Mohammed Qasim Rauf
  - Calvin R Wei
  - Adil Amin
- PubMed: 40895855
- DOI: 10.7759/cureus.88949
4 Insights on
- Reduced Aspartate Aminotransferase Levels
- Low evidence
- Clinical
aspartate aminotransferase levels (MD: -7.08; 95% CI: -14.93 to 0.76)
Effect
Neutral
Effect size
Small
Significant
No
Dose
300 to 800 mg daily