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Evidence-Based Supplement Research
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Vitamin E and Reduced Malondialdehyde Level

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, findings are mixed: one meta-analysis reported a beneficial large effect on reducing malondialdehyde levels in epilepsy patients, while two individual RCTs in MASLD and infertile men found neutral small effects. The only statistically significant result came from the meta-analysis. Median study duration was 129 days, and doses ranged from 100 mg to 400 mg twice daily, with no consistent form reported.

  • Studied populations: Epilepsy patients (beneficial effect observed in a meta-analysis)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Additionally, the beneficial effect was observed only in a meta-analysis of epilepsy patients; individual RCTs in other populations showed no significant effect, suggesting potential population specificity.

Generated Jul 11, 2026
Doses used in studies
  • mg/day: 200–800 (median 500, IQR 350–650) — 2 studies
Time to effect
Median: 4.3 months · IQR 3.7 months–5 months · Range 3 months–5.6 months — Reported in 2 of 3 studies
3 of 3 papers
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