Vitamin E and Reduced Tissue Inhibitor of Metalloproteinase 1 Level

• New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.

  • 2025-08
  • RCT · n = 45
  • Clinical therapeutics 47(8)
  • • Amr Y Zakaria
    • Rehab Badawi
    • Hasnaa Osama
    • Mona A Abdelrahman
    • Asmaa M El-Kalaawy

  • PubMed: 40480879
  • DOI: 10.1016/j.clinthera.2025.05.006

  13 Insights on

  • Reduced Tissue Inhibitor of Metalloproteinase 1 Level

  • High evidence
  • Clinical

  Group 2 exhibited substantial reductions in mean levels of all biological markers: ... tissue inhibitor of metalloproteinases 1 by 10.28% (P < 0.05)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  1200 mg twice daily