Vitamin K and Improved Progression-free Survival

• The role of vitamin K in the prognosis of patients with hepatocellular carcinoma: a systematic review and meta-analysis.

  • 2026-03-18
  • Systematic Review · n = 688
  • Frontiers in oncology 16
  • • Lang Guo
    • Yaqiong Wang
    • Zhenkun Tan
    • Tingli Lu
    • Zha Peng
    • Hai Huang

  • PubMed: 41930200
  • DOI: 10.3389/fonc.2026.1765445

  3 Insights on

  • Improved Progression-free Survival

  • High evidence

  this combination prolonged PFS (pooled HR = 0.62, 95% CI: 0.47-0.82)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Anticancer effects of vitamin K combined with transarterial chemoembolization in hepatocellular carcinoma, a randomized controlled trial.

  • 2025-04-22
  • RCT · n = 51
  • British journal of cancer 132(12)
  • • Yoshimichi Haruna
    • Takayuki Yakushijin
    • Miho Yamakawa
    • Tetsuo Nakazawa

  • PubMed: 40263401
  • DOI: 10.1038/s41416-025-03022-4

  3 Insights on

  • Improved Progression-free Survival

  • High evidence
  • Clinical

  The PFS was significantly longer in the TACE + vitamin K group than that in the TACE alone group (median time: 262 days [95% confidence interval (CI), 35.8-488.2 days] vs. 146 days [95% CI, 111.6-180.4 days]; p = 0.013, hazard ratio: 0.55 [95% CI, 0.34-0.89]).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes