Vitamin K1 and Increased Time to Acneiform Rash Onset

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityNo significant differenceHR=1.33; 95% CI, 0.57-3.10; p=0.507
Prophylactic application of topical vitamin K1 cream did not decrease the risk of acneiform rash (HR=1.33; 95% CI, 0.57-3.10; p=0.507).
from: Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab trea

1 of 1 paper

Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer.

The median time to grade≥2 rash in the experimental group was 4 weeks compared to 6 weeks in the historical control group (p=0.340).