The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
- 2022-01
- RCT · n = 149
- The American journal of clinical nutrition 115(1)
- Jamie W Bellinge
- Roslyn J Francis
- Sing C Lee
- Nicola P Bondonno
- Marc Sim
- Joshua R Lewis
- Gerald F Watts
- Carl J Schultz
- PubMed: 34637494
- DOI: 10.1093/ajcn/nqab306
- High evidence
- Large Human Trial
- Clinical
Vitamin K1 supplementation independently decreased the odds of developing new 18F-NaF PET positive lesions in the coronary arteries (OR: 0.35; 95% CI: 0.16, 0.78; P = 0.010), aorta (OR: 0.27; 95% CI: 0.08, 0.94; P = 0.040), and in both aortic and coronary arteries (OR: 0.28; 95% CI: 0.13, 0.63; P = 0.002).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 10 mg/d