Randomized, placebo-controlled trial of orally administered vitamin K1 for warfarin-associated coagulopathy in Chinese patients with mechanical heart valves.
- 2021-03-30
- RCT · n = 80
- European journal of clinical pharmacology 77(9)
- Heng Zhang
- Mei Li
- Xue-Lian Ao
- Yi-Jun Dong
- Li Dong
- PubMed: 33783553
- DOI: 10.1007/s00228-021-03127-8
- High evidence
- Clinical
Lower bleeding incidence was observed among patients administered vitamin K1 relative to those administered placebo during follow-up (4 [10%] vs. 12 [30%] patients, respectively, p = 0.045).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 2.5 mg