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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin K1 and Reduced Bone Mineral Density

Doses used in studies

mcg/day: 200 (median 200, IQR 200–200) — 1 study

Time to effect

Median: 24.3 months · IQR 24.3 months–24.3 months · Range 24.3 months–24.3 months — Reported in 1 of 1 study

1 of 1 paper

Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.
- 2007-04-01
- RCT · n = 244
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22(4)
- - Caroline Bolton-Smith
  - Marion E T McMurdo
  - Colin R Paterson
  - Patricia A Mole
  - Julia M Harvey
  - Steven T Fenton
  - Celia J Prynne
  - Gita D Mishra
  - Martin J Shearer
- PubMed: 17243866
- DOI: 10.1359/jbmr.070116
3 Insights on
- Reduced Bone Mineral Density
- High evidence
- Large Human Trial
- Highly Cited
- Elderly
Significant bone mineral loss was seen only at the mid-distal radius but with no significant difference between groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
200 μg/day