Vitamin K1 and Reduced PIVKA-II Concentration

Doses used in studies

mg single-dose: 1 (median 1, IQR 1–1) — 1 study

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 1 study

1 of 1 paper

Vitamin K insufficiency and the prophylaxis strategy in term healthy infants: A multicentre study.

2023-12-09
Observational
European journal of clinical investigation 54(4)
- Serafina Perrone
- Giuseppe De Bernardo
- Chiara Lembo
- Valentina Dell'Orto
- Maurizio Giordano
- Virginia Beretta
- Chiara Petrolini
- Lucia Gambini
- Anna Laura Toni
- Gianni Parigi
- Ilenia Fontanarosa
- Maria Pia Natale
- Gabriele D'Amato
- Desiree Sordino
- Giuseppe Buonocore

PubMed: 38071415
DOI: 10.1111/eci.14141

1 Insight on

Reduced PIVKA-II Concentration

Low evidence
Infants

The prophylaxis involving a dose of 1 mg of intramuscular VK1 at birth followed by oral administration of 150 μg/day of VK1 from the 2nd to the 14th week of life showed the lowest PIVKA-II blood concentrations.

Effect: Beneficial
Effect size: Large
Significant: Yes
Dose: 1 mg intramuscular at birth followed by oral 150 μg/day from 2nd to 14th week