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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin K1 and Reduced Undercarboxylated Osteocalcin Level

Doses used in studies

μg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

1 of 1 paper

The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial.
- 2015-03-18
- RCT · n = 43
- European journal of clinical nutrition 69(8)
- - H Rasekhi
  - M Karandish
  - M T Jalali
  - M Mohammad-Shahi
  - M Zarei
  - A Saki
  - H Shahbazian
- PubMed: 25782427
- DOI: 10.1038/ejcn.2015.17
5 Insights on
- Reduced Undercarboxylated Osteocalcin Level
- High evidence
- Rigorous Journal
- Clinical
intake of phylloquinone supplement led to significant decreases in %ucOC (17.97 ± 12.24 compared with 43.80 ± 19.86)... compared with placebo.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
1000 μg/day