Vitamin K1 and Reduced Undercarboxylated Osteocalcin Level

Doses used in studies

mcg/day: 200 (median 200, IQR 200–200) — 1 study
μg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 12.6 months · IQR 6.8 months–18.5 months · Range 4 weeks–24.3 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.
- 2007-04-01
- RCT · n = 244
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22(4)
- - Caroline Bolton-Smith
  - Marion E T McMurdo
  - Colin R Paterson
  - Patricia A Mole
  - Julia M Harvey
  - Steven T Fenton
  - Celia J Prynne
  - Gita D Mishra
  - Martin J Shearer
- PubMed: 17243866
- DOI: 10.1359/jbmr.070116
3 Insights on
- Reduced Undercarboxylated Osteocalcin Level
- High evidence
- Large Human Trial
- Highly Cited
- Elderly
the percentage of undercarboxylated osteocalcin (%GluOC) decreased by 51% (p < 0.001)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
200 μg/day
The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial.
- 2015-03-18
- RCT · n = 43
- European journal of clinical nutrition 69(8)
- - H Rasekhi
  - M Karandish
  - M T Jalali
  - M Mohammad-Shahi
  - M Zarei
  - A Saki
  - H Shahbazian
- PubMed: 25782427
- DOI: 10.1038/ejcn.2015.17
5 Insights on
- Reduced Undercarboxylated Osteocalcin Level
- High evidence
- Rigorous Journal
- Clinical
intake of phylloquinone supplement led to significant decreases in %ucOC (17.97 ± 12.24 compared with 43.80 ± 19.86)... compared with placebo.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
1000 μg/day

Vitamin K1 and Reduced Undercarboxylated Osteocalcin Level

Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.

The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial.