Vitamin K2 and Increased Adverse Reactions

• Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.

  • 2022-06-16
  • Meta-Analysis · n = 6,853
  • Journal of bone and mineral metabolism 40(5)
  • • Ming Zhou
    • Shiliang Han
    • Wenpeng Zhang
    • Dan Wu

  • PubMed: 35711002
  • DOI: 10.1007/s00774-022-01342-6

  2 Insights on

  • Increased Adverse Reactions

  • High evidence
  • Clinical

  Adverse reaction analysis showed that there seemed to be higher adverse reaction rates in the vitamin K2 group (RR = 1.33, 95% CI [1.11-1.59]), but no serious adverse events related to vitamin K2 supplementation.

  Effect

  Harmful

  Effect size

  Moderate

  Significant

  Yes