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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin K2 and Increased Gastrointestinal Discomfort

Doses used in studies

mcg/day: 360 (median 360, IQR 360–360) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

1 of 1 paper

Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial.
- 2022-05
- RCT · n = 523
- Nutrition (Burbank, Los Angeles County, Calif.) 97
- - Dan Xu
  - AnXiu Yang
  - Ruijun Ren
  - Zhong Shan
  - Yuan Ming Li
  - Jing Tan
- PubMed: 35203045
- DOI: 10.1016/j.nut.2022.111608
4 Insights on
- Increased Gastrointestinal Discomfort
- High evidence
- Large Human Trial
- Clinical
One patient experienced gastrointestinal discomfort when taking vitamin K2.
Effect
Harmful
Effect size
Small
Dose
360 µg/d