Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial.
- 2022-05
- RCT · n = 523
- Nutrition (Burbank, Los Angeles County, Calif.) 97
- Dan Xu
- AnXiu Yang
- Ruijun Ren
- Zhong Shan
- Yuan Ming Li
- Jing Tan
- PubMed: 35203045
- DOI: 10.1016/j.nut.2022.111608
- High evidence
- Large Human Trial
- Clinical
Vitamin K2 reduced the frequency, duration, and severity of muscle cramps in HD patients (all P < 0.05).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 360 µg/d