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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Astaxanthin and Increased Antioxidant Enzyme Levels

Doses used in studies

mg/day: 12–20 (median 16, IQR 14–18) — 2 studies

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
The abstract does not mention any adverse events or side effects related to astaxanthin supplementation.
from: Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart fail

2 of 2 papers

Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial.
- 2025-10-29
- RCT · n = 80
- BMC cardiovascular disorders 25(1)
- - Shirin Ghotboddin Mohammadi
  - Davood Shafie
  - Awat Feizi
  - Mohammad Bagherniya
  - Ali-Reza Ahmadi
  - Marzieh Kafeshani
- PubMed: 41162864
- DOI: 10.1186/s12872-025-05260-z
7 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Clinical
participants receiving ASX supplementation showed a significant increase in ... SOD levels (156.92 vs. 36.14 U/mL, P < 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
20 mg/day
Astaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial.
- 2024-10-31
- RCT
- Journal of ovarian research 17(1)
- - Anahid Shafie
  - Ashraf Aleyasin
  - Mojtaba Saffari
  - Mojtaba Saedi
  - Sahar Rostami
  - Saeede Rezayi
  - Seyed Danial Mohammadi
  - Fardin Amidi
- PubMed: 39482765
- DOI: 10.1186/s13048-024-01537-7
12 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Clinical
No significant differences between AST and placebo groups were observed in OS markers in FF.
Effect
Neutral
Effect size
Small
Significant
No
Dose
12 mg/day