bifidobacterium longum and Improved Insulin Resistance

• Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

  • 2011-09-08
  • RCT · n = 66
  • Digestive Diseases and Sciences 57(2)
  • • M. Malaguarnera
    • M. Vacante
    • T. Antić
    • M. Giordano
    • G. Chisari
    • R. Acquaviva
    • S. Mastrojeni
    • G. Malaguarnera
    • A. Mistretta
    • G. Volti
    • F. Galvano

  • PubMed: 21901256
  • DOI: 10.1007/s10620-011-1887-4

  17 Insights on

  • Improved Insulin Resistance

  • High evidence
  • Highly Cited
  • Rigorous Journal

  we observed that the Bifidobacterium longum with Fos and lifestyle modification group versus the lifestyle modification alone group showed significant differences in the AST -69.6 versus -45.9 IU/mL (P < 0.05), LDL cholesterol -0.84 versus -0.18 mmol/L (P < 0.001), CRP -2.9 versus -0.7 mg/L (P < 0.05), TNF-α -0.45 versus -0.12 ng/mL (P < 0.001), HOMA-IR -1.1 versus -0.6 (P < 0.001), serum endotoxin -45.2 versus -30.6 pg/mL (P < 0.001), steatosis (P < 0.05), and the NASH activity index (P < 0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes